BACKGROUND Although alterations in not only the pain sensitivity but also the analgesic effects of opioids have been reported under conditions of stress, the influence of unpredictable chronic mild stress (UCMS) on the antinociceptive effects of opioid analgesics remains to be fully investigated. The present study examined the influence of UCMS on the thermal pain sensitivity and antinociceptiv...

foeniculum vulgare (fennel) has been widely used in traditional medicine for treatment of variousdiseases including pediatric colic. this study was designed to assess the antinociceptive effects of aqueousextract of f. vulgare on visceral pain and possible involvement of opioidergic, serotonergic, adrenergic andhistaminergic systems. the results of this study showed that aqueous extract of f. v...

BACKGROUND & OBJECTIVES Several studies have shown the possible analgesic effects of gabapentin, widely used as an antiepileptic. Thus, clinical studies have been carried out especially for neuropathic syndroms. This study was undertaken to investigate experimentally whether gabapentin has analgesic effects in mice and rats. METHODS The mice were divided into 10 groups (n=7) with various trea...

Intrathecal administration of delta 9-tetrahydrocannabinol (delta 9-THC) but not the cannabinoid agonist CP55,940 enhances the antinociception produced by morphine. In addition, CP55,940- and delta 9-THC-induced antinociception is blocked by the kappa opioid antagonist norbinaltorphimine, and both cannabinoids are cross-tolerant to kappa agonists but do not act directly at the kappa receptor. P...

there are several reports that adenosine and carbamazepine have pharmacodynamic interaction. i n this study the antinociceptive interaction o f these two agents was evaluated in mice by the hot plate test. agents were injected intraperitoneally. 0.2 and 0.4 mg/kg doses of r-phenylisopropyladenosine (r-pia) substantially showed antinociceptive effects. carbamazepine had antinociceptive actions e...

Convolutamydine A, an oxindole that originated from a marine bryozoan, has several biological effects. In this study, we aimed to investigate the antinociceptive effects of convolutamydine A and two new synthetic analogues. Convolutamydine A and the two analogues were given orally to assess their ability to induce antinociceptive effects. Formalin-induced licking response, acetic acid-induced c...

our previous study showed that coriandrum sativum (cs) has antinociceptive effects, but the mechanisms that mediate this effect are not clear. the present study was designed to test the role of opiate system in the antinociceptive effects of cs on acute and chronic pain in mice using hot plate (hp), tail flick (tf) and formalin (ft) tests and also to compare its effect with dexamethasone (dex) ...

Foeniculum vulgare (fennel) has been widely used in traditional medicine for treatment of variousdiseases including pediatric colic. This study was designed to assess the antinociceptive effects of aqueousextract of F. vulgare on visceral pain and possible involvement of opioidergic, serotonergic, adrenergic andhistaminergic systems. The results of this study showed that aqueous extract of F. v...